Hotan Prefecture is located at the southwestern edge of Taklimakan Desert,the world's largest shifting sand desert, of China. The desert is one of the main sources for frequent sand-dust weather events whichstrongly affectthe air quality of Hotan Prefecture.Although this region is characterized by the highest annual mean PM₁₀ concentration values that are routinely recorded by environmental monitoring stations across China, both this phenomenon and its underlying causes have not been adequately addressed in previous researches. Reliable pollutant PM₁₀ data are currently retrieved using a tapered element oscillating microbalance (TEOM) 1400a, a direct real-time monitor, while additional concentration values including for PM_2.5, sulfur dioxide (SO₂), nitrogen dioxide (NO₂), carbon monoxide (CO) and ozone (O₃) have been collected in recent years by the Hotan Environmental Monitoring Station. Based on these data, this paper presents a comparison of the influences of different kinds of sand-dust weather events on PM₁₀ (or PM_2.5) as well as the concentrations of other gaseous pollutants in Hotan Prefecture. It is revealed that the highest monthly average PM₁₀ concentrations are observed in the spring because of the frequent occurrence of three distinct kinds of sand-dust weather events at this time, including dust storms, blowing dust and floating dust. The floating dust makes the most significant contribution to PM₁₀ (or PM_2.5)concentration in this region, a result that differs from eastern Chinese cities where the heaviest PM₁₀ pollution occurs usually in winter and air pollution results from the excess emission of local anthropogenic pollutants. It is also shown that PM₁₀ concentration varies within typical dust storms. PM₁₀ concentrations vary among 20 dust storm events within Hotan Prefecture, and the hourly mean concentrations tend to sharply increase initially then slowly decreasing over time. Data collected from cities in eastern China show the opposite with the hourly mean PM₁₀ (or PM_2.5)concentration tending to slowly increase then sharply decrease during heavy air pollution due to the excess emission of local anthropogenic pollutants. It is also found that the concentration of gaseous pollutants during sand-dust weather events tends to be lower than those cases under clear sky conditions. This indicates that these dust events effectively remove and rapidly diffuse gaseous pollutants. The analysis also shows that the concentration of SO₂ decreases gradually at the onset of all three kinds of sand-dust weather events because of rapidly increasing wind velocity and the development of favorable atmospheric conditions for diffusion. In contrast, changes in O₃ and NO₂ concentrations conformed to the opposite pattern during all three kinds of sand-dust weather events within this region, implying the inter transformation of these gas species during these events.