Central Asia is located in the hinterland of Eurasia, comprising Kazakhstan, Uzbekistan, Kyrgyzstan, Turkmenistan, and Tajikistan; over 93.00% of the total area is dryland. Temperature rise and human activities have severe impacts on the fragile ecosystems. Since the 1970s, nearly half the great lakes in Central Asia have shrunk and rivers are drying rapidly owing to climate changes and human activities. Water shortage and ecological crisis have attracted extensive international attention. In general, ecosystem services in Central Asia are declining, particularly with respect to biodiversity, water, and soil conservation. Furthermore, the annual average temperature and annual precipitation in Central Asia increased by 0.30°C/decade and 6.9 mm/decade in recent decades, respectively. Temperature rise significantly affected glacier retreat in the Tianshan Mountains and Pamir Mountains, which may intensify water shortage in the 21^st century. The increase in precipitation cannot counterbalance the aggravation of water shortage caused by the temperature rise and human activities in Central Asia. The population of Central Asia is growing gradually, and its economy is increasing steadily. Moreover, the agricultural land has not been expended in the last two decades. Thus, water and ecological crises, such as the Aral Sea shrinkage in the 21^st century, cannot be attributed to agriculture extension any longer. Unbalanced regional development and water interception/transfer have led to the irrational exploitation of water resources in some watersheds, inducing downstream water shortage and ecological degradation. In addition, accelerated industrialization and urbanization have intensified this process. Therefore, all Central Asian countries must urgently reach a consensus and adopt common measures for water and ecological protection.